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| Name | Potential new drug treats blood disorders by halting overproduction of blood cells |
| Video Uploader | Video From UF Health |
| Upload Date | This Video Uploaded At 24-02-2011 20:05:33 |
| Video Discription | Like a switch stuck in the on position, the bone marrow can churn out blood cells that bloat internal organs and clog blood vessels, leading to life-threatening disease. Now University of Florida scientists have discovered a potential new drug that can throw the switch on the runaway blood cell-production mechanism. The drug shrinks cell-gorged organs and stems the overproduction of blood cells, and the researchers are working toward bringing it into clinical trial in one year. "The disease has a path it's going to take and you need to be able to alter that path — our drug does that to a reasonable extent," said Peter P. Sayeski, Ph.D., an associate professor of physiology and functional genomics in the UF College of Medicine, who led the research team. The work, funded in part by the National Institutes of Health and the American Heart Association, is described in the current issue of the Journal of Biological Chemistry. The new drug, dubbed "G6" by the researchers, targets a group of life-threatening and hard-to-diagnose diseases called myeloproliferative neoplasms, or MPNs, that occur when the bone marrow cranks out too many red cells, white cells or platelets because of a mutant form of a protein called Jak2 that is key to blood cell formation. The condition is estimated to affect about 170,000 people in the United States, according to data from the MPN Research Foundation, also known as the MPD Foundation. "These bone marrow cells are replicating and growing out of control because one very important protein is stuck in the on position," said Christopher R. Cogle, M.D., an associate professor of hematology/oncology in the UF College of Medicine and a member of the UF Shands Cancer Center. The result is blood counts so high they elevate patients' risk of stroke, bleeding, infection and blood clots in various parts of the body. Ironically, the condition can also lead to low blood cell count and anemia symptoms, because it impedes the flow of normal cells from the bone marrow into the blood stream. |
| Category | News & Politics |
| Tags | 022411Jak2 | mutation |
