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| Name | CMap Analysis - Candidate Therapeutic Discovery Based on Disease-Drug Transcriptomic Similarity |
| Video Uploader | Video From Precision Health |
| Upload Date | This Video Uploaded At 26-07-2021 10:21:53 |
| Video Discription | The method of drug discovery based on drug-drug similarity has two principal limitations: (1) one needs to have at least one known drug or compound to query the database and (2) the discovered new compounds may mostly belong to the same class as the queried drug or compound. Therefore, in order to find potential therapeutics for disease that has no known therapeutic, one has to explore the “connectivity” between the queried disease and all known or investigational drugs. In the following example, using psoriasis, an immune-mediated, inflammatory, and hyperproliferative disease of the skin and joints, we will present a step-by-step approach to find novel candidate therapeutics for psoriasis. |
| Category | Science & Technology |
| Tags | ConnectivityMap | drug discovery | data science | algorithms | Broad Institute | connectivity map clue | connectivity map drug repurposing | connectivity map (cmap) database | connectivity map lamb | connectivity map score | connectivity map cell lines | connectivity map l1000 | connectivity map tutorial | Computational Biology | Gene Expression | precision medicine | connectivity mapping methods and applications |
