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| Name | Gilbert syndrome |
| Video Uploader | Video From Air to air |
| Upload Date | This Video Uploaded At 13-09-2021 14:21:40 |
| Video Discription | (hyperbilirubinemia type 1, Meulengracht syndrome) A genetic liver disorder, where the patients inherit mutated UGT1A1 gene. They do not produce enough an enzyme, uridine diphosphate glucuronosyltransferase (UGT) to keep bilirubin at a normal level. As a result, excess bilirubin builds up in the body (hyperbilirubinemia). Many people never have symptoms. Occasionally, jaundice, fatigue, weakness, and abdominal pain may occur. Typically no treatment is needed. (Signs and symptoms) • Jaundice. • Dark-colored urine and clay-colored (pale) stool. • Flu-like symptoms (fever and chills). • Loss of appetite, fatigue, dizziness. • Nausea, abdominal pain, diarrhea. (Triggers that bring the symptoms) • Dehydration. • Fasting or skipping meals. • Not getting enough sleep. • Stress. • Overexertion. • Menstruation. • Illness with an infection. • Having surgery. (Decreased detoxification ability to some drugs in the liver) • irinotecan: An analogue of camptothecin (topoisomerase inhibitor) used in cancer chemotherapy. It is hydrolyzed by carboxylesterases and forms SN-38, which is metabolized via glucuronidation by UGT in the liver and excreted into the bile. Decreased UGT activity may lead to severe toxicity (diarrhea and neutropenia). • paracetamol (acetaminophen): A medication used to treat fever and mild to moderate pain. It is metabolized primarily in the liver, mainly via glucuronidation and sulfation (as well as via oxidation by cytochrome P450 enzymes and deacetylation), and the products are then eliminated in the urine. It can cause acute liver failure (hepatotoxicity) by overdose. Cf. Crigler-Najjar syndrome, Dubin Johnson syndrome |
| Category | Education |
| Tags | Education Download MP4 | Education Download MP3 | Education Download MP4 360p | Education Download MP4 480p | Education Download MP4 720p | Education Download MP4 1080p |
