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| Name | Zhijian “James” Chen - The Dark Side of DNA - How the Immune System Senses DNA as a Danger Signal |
| Video Uploader | Video From Celebrating DNA Double Helix's 70th |
| Upload Date | This Video Uploaded At 03-01-2024 03:10:32 |
| Video Discription | Professor Chen briefly introduced the discovery of cGAS, an intracellular DNA receptor, and the signal transduction of the cGAS-STING pathway. Abnormalities in this pathway may lead to autoimmune diseases, such as Aicardi-Goutières Syndrome (AGS), which is associated with mutations in the DNA exonuclease Trex1. Chen's team confirmed the hypothesis in a Trex1-deficient mouse model, suggesting that cGAS is a therapeutic target for AGS and possibly other autoimmune diseases. The Chen lab also revealed the immune mechanism of bacteria against phage infection by analyzing cGAS-like proteins in prokaryotes. |
| Category | Science & Technology |
| Tags | Science & Technology Download MP4 | Science & Technology Download MP3 | Science & Technology Download MP4 360p | Science & Technology Download MP4 480p | Science & Technology Download MP4 720p | Science & Technology Download MP4 1080p |
