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| Name | Toward a Universal Influenza Virus Vaccine |
| Video Uploader | Video From NIH VideoCast |
| Upload Date | This Video Uploaded At 02-05-2014 20:29:00 |
| Video Discription | Toward a Universal Influenza Virus Vaccine Air date: Wednesday, April 30, 2014, 3:00:00 PM Category: Wednesday Afternoon Lectures Runtime: 00:51:42 Description: Wednesday Afternoon Lecture Series Because influenza viruses are constantly changing, it's difficult to develop effective vaccines against them. Two molecules on the surface of the virus control its infectivity: hemagglutinin and neuraminidase. Current influenza virus vaccines predominantly elicit a protective immune response to the immunodominant but variable head of the hemagglutinin. This approach is effective, especially when the vaccine strain closely matches the circulating virus. Another vaccine strategy involves redirecting the response to the more conserved stalk domain of the hemagglutinin and the immunosubdominant neuraminidase. This can be achieved by using vaccine strains that express chimeric hemagglutinin proteins whereby the head of the hemagglutinin represents an exotic subtype never encountered by humans under natural conditions. Such influenza virus constructs are likely to boost memory B-cells directed against conserved epitopes of the hemagglutinin stalk and the neuraminidase, and thus should afford broad spectrum protection against a variety of antigenic drift and shift strains. For more information go to http://wals.od.nih.gov Author: Peter Palese, Ph.D., Professor and Chair, Department of Microbiology, Mount Sinai School of Medicine Permanent link: http://videocast.nih.gov/launch.asp?18409 |
| Category | Science & Technology |
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